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ea0097002 | Section | BES2023

Protein tyrosine phosphatase receptor kappa regulates glycolysis, lipid metabolism and promotes hepatocyte reprogramming in obesity

Eduardo H Gilglioni , Li Ao , Wadsen St-Pierre-Wijckmans , Tzu-Keng Shen , Israel Perez-Chavez , Garnik Hovhannisyan , Daria Ezerina , Michela Lisjak , Andre Dias , Javier Negueruela , Mamnez Julia Bauza- , Jose Maria Herranz , Stephane Demine , Zheng Feng , Thibaut Vignane , Lukas Otero , Flavia Lambertucci , Alena Prasnicka , Jacques Deviere , Jose Antonio Encinas , Sumeet Pal Singh , Joris Messens , Milos Filipovic , Eric Trepo , Hayley Sharpe , Wei Wu , Esteban N Gurzov

Fat accumulation, lipogenesis and glycolysis are key contributors to hepatocyte metabolic reprogramming and the pathogenesis of non-alcoholic liver fatty liver disease (NAFLD). The molecular mechanisms affected by steatosis and inflammation in the obese state remain unknown. Here we report that obesity leads to dysregulated expression of protein-tyrosine phosphatases in human livers. Protein Tyrosine Phosphatase Receptor Kappa (PTPRK) levels were increased in hepatocytes by st...

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Protein tyrosine phosphatase receptor kappa regulates glycolysis, lipid metabolism and promotes hepatocyte reprogramming in obesity

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